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In rat lungs and human bronchi, CuZnSOD was prominent in macrophages and bronchiolar epithelial cells, suggesting protective mechanisms in both target cells of lung cancers and effector cells of the immune system

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Binding couples predominantly to Gs and adenylyl cyclase, raising intracellular cAMP, activating PKA, driving CREB phosphorylation and voltage-dependent calcium influx, and triggering exocytosis of stored growth hormone (GH)