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Hence, a major discovery of this study underscores the pro-oxidative role of NF-kB signaling in response to LPS/ATP stimulation, which leads to an increase in ROS accumulation and macrophage pyroptosis
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The basic idea involves a linkage of a nuclear hormone to a peptide, usually through a linker that would allow metabolism of the nuclear hormone only within the targeted cell reducing the undesirable effects in other tissues
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