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The chemical similarity analysis performing by ligand-based virtual or HTS screening identified ethionamide ( 26a ) and its analogs ( 26c – 26e ), including prothionamide ( 26b ), as tyrosinase inhibitors 95 (Figure 9(a))
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Results: Cell viability of 2′-H-5′-M-3′-N was very low against PC-14, LC-2/ad, and HLC-1 cell lines without any cytotoxicity towards the normal cell line
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