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Upon activation, IRE1 splices the mRNA of X-box binding protein 1 (XBP1), leading to the formation of the transcription factor sXBP1 [169,170,171]

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There are studies that have been done on the skin lightening effects of glutathione, but they aren’t voluminous and hence the use of this skin whitening treatment is mainly based on empirical evidence, which is observation of visible change by practitioners