glutathione disulfiram The interaction of and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth mechanism of action of disulfiram in alcoholism

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Co-administration of HIF inhibitors with immune checkpoint blockade (e.g., anti-PD-1/PD-L1), angiogenesis inhibitors (e.g., bevacizumab), or metabolic modulators (e.g., glutaminase inhibitors) may produce synergistic antitumor responses

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In the mitochondria the acetyl-CoA is diverted into the ketone synthesis pathway producing acetoacetate which, due to the elevated NADH levels, is preferentially converted to β-hydroxybutyrate