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In this regard, other disease states such as non-alcoholic fatty liver disease (NAFLD) or chronic hepatitis C virus infection, and ischemia/hypoperfusion caused by heart failure or atherosclerosis result in increased accumulation of lipid peroxidation products and adduct formation.113,114 When combined with chronic alcohol abuse, these co-factors increase risk for progression to cirrhosis and/or HCC.115 Conditions that lead to increased iron deposition and consequently potentiate radical ion formation such as hemachromatosis,35 or ADH and ALDH gene polymorphisms that impair efficient metabolism of alcohol to carbon dioxide and water, could serve as co-factors in promoting end-stage liver disease or HCC

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The IOM concentration of 18 μg/L was based on consideration of a subset of mature milk samples collected from United States and Canadian mothers, in which the range of milk selenium concentration was 15–20 μg/L [57]