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Consistent with these findings, Gene Set Enrichment Analysis (GSEA) revealed enrichment of the SenMayo 30 and ferroptosis pathways in aged oocytes, indicating their transcriptional activation during oocyte aging, which were significantly attenuated by uridine supplementation, thereby reducing senescence-associated transcriptional features (Fig
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An increase in lipid peroxidation could affect the properties of the membrane and cellular homeostasis leading to apoptosis (Yadav et al., 2019)
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