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Pro-inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6 cross the blood-brain barrier, activate microglia, and directly interfere with neurotransmitter synthesis
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DOI: 10.1530/EC-19-0382 Zhang Y et al, "Using corneal confocal microscopy to compare Mecobalamin intramuscular injections vs oral tablets in treating diabetic peripheral neuropathy: a RCT." Scientific Reports, July 19, 2021
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