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10.1016/j.fct.2021.112250 22 MalhiG

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Among these genes, the most widely studied gene polymorphisms associated with asthma patients, affecting the lung function, include IL33, IL1RL1, IL13, thymic stromal lymphopoietin (TSLP), and HLA ( Psychological stress resulting from various lifestyle factors, like violence, lower socioeconomic status, occupational and domestic problems, and academic examinations, has been shown to augment airway inflammation, contributing to the severity of asthma ( Moreover, other emotional stressors, like depression or anxiety, have been reported to stimulate airway constriction in adult asthma patients ( 3.1.2 The anatomical components layer The second layer from bottom, as shown in Figure 3 , represents cellular components of the airway and CNS microenvironment: bronchial epithelial cells, dendritic cells, macrophages, innate lymphoid cells, CD4+ naïve T cells, Th1 cells, Th2 cells, Th17 cells, Treg cells, CD8+ T cells, eosinophils, neutrophils, B cells, mast cells, basophil, ASMC, fibroblasts, myofibroblast, endothelial cells, pericytes, microglia, adrenal cortex and medulla cells, mucosal gland cells, neurons such as paraventricular nuclei (PVN) of hypothalamus, amygdala brain neurons, brainstem neurons, pituitary neurons, sympathetic neurons, afferent vagal sensory neurons, efferent parasympathetic cholinergic and noncholinergic neurons