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Reviews of the pharmaceutical use of sermorelin, that is GRF 1-29, report a short plasma half-life of about 10 to 20 minutes in humans, attributed mostly to renal ultrafiltration and enzymatic degradation (a peer-reviewed Advanced Drug Delivery Reviews paper identifying sermorelin as GRF 1-29 and reporting its short plasma half-life of about 10 to 20 minutes in humans)
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