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Immune suppressants should be utilized in all sick cases with grade 3 or 4 CRS and, therefore, should be started earlier in patients with substantial comorbidity or the elderly (Shimabukuro-Vornhagen et al., 2018) In Figure 3A, type II pneumocytes in airways and alveoli are first infected by SARS-CoV-2, which causes alveolar macrophages to become activated, cytokines to be produced, and further inflammatory infiltration
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