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Following screening, patients entered a 24-week core period where they received an initial dose of mitapivat 50 mg twice a day orally

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Synthesis and Manufacturing Industrial Synthesis Routes Two primary methods dominate the synthesis of 4-Hexen-1-yne, (4E)-: Dehydrohalogenation of Haloalkenes Treatment of 1,4-dihalohex-4-ene with a strong base (e.g., KOH) induces sequential elimination of HX, forming the alkyne and alkene groups