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As detailed in Canham’s analysis, the clinical metrics demonstrate a clear separation between peripheral auditory stabilization and vestibular symptom control: Low-Frequency Pure-Tone Thresholds: Evaluating low-frequency pure-tone thresholds at 250 Hz, 500 Hz, and 1000 Hz revealed that 52.7% of subjects on SPI-1005 achieved a 10 dB or greater improvement in at least one frequency, compared to 37.0% in the placebo group

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From this cohort, 45 women [15 without mood disorders and 30 with mood disorders (Major depression and Bipolar disorder)] were selected at 18 months postpartum, the depression and suicide risk were assessed using the Mini-International Neuropsychiatric Interview Plus (MINI-Plus) instrument, module A and C, respectively

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