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The current lack of large-scale, integrated cohort studies combining genomic, microbiota, metabolomic, and immune profiling further restricts the establishment of definitive causal links and the development of evidence-based therapeutic strategies ( 4 Future perspectives and conclusion 4.1 Addressing heterogeneity: tumor type, spatio-temporal dynamics, and host factors A critical frontier in harnessing the gut microbiota-bile acid (BA) axis for cancer therapy is addressing the profound heterogeneity of its influence on the TIME

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