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However, we disagree with the main conclusion of this paper, which states that most or all the differences in microbiome composition reported previously are only because of diet and that there is no actual link between the gut microbiome and ASD

in vitro research only

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54 Metformin has been demonstrated to impair vitamin B 12 absorption, 44,55–59 and concentrations of the vitamin in serum have been inversely correlated with both dose and length of therapy with the medication