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During adolescence, high insulin levels caused by IR may disrupt the gonadotropin-releasing hormone (GnRH) signaling pathway and induce HA through multiple pathways, thereby affecting the establishment of ovulatory function
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Similarly, neutrophils and macrophages become activated as part of the host defense system as well as the inflammatory response, which produces a large amount of RNS and ROS, followed by the entry of these ROS into the erythrocytes [406]
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