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Pathogenesis of SARS Speaking of pathogenesis, SARS begins with the exudative phase, characterized by a response mediated by innate immune cells of the alveolar endothelial and epithelial barriers as well as the accumulation of protein-rich fluids in the interstitium and alveolus
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Interestingly, they observed that, in this specific experimental setting, lactoferrin-mediated protection was independent of its iron-chelating ability, as the molecule itself underwent degradation and partial aggregation upon stimulation, thus acting as a sacrificial ROS scavenger, directly interacting with hydrogen radicals to protect cellular DNA from oxidative injury [79]
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