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CD8 + T cell populations have been detected within human and murine atherosclerotic plaques
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GCH1-mediated defense mechanism GTP cyclohydrolase-1 (GCH1) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4), a critical cofactor necessary for various biochemical processes, including the synthesis of monoamine neurotransmitters and the regulation of nitric oxide levels (178,179)
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