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The consequences of Nrf2 impairment in CF include weakened intrinsic antioxidant defense capacity and increased intracellular H 2 O 2 levels, which contribute to the overproduction of pro-inflammatory cytokines like IL-6 and IL-8, directly linking defective antioxidant response to CF’s characteristic chronic inflammation (Chen et al., 2008)

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3 The amygdala controls the body’s fight-or-flight response, which is activated in situations that are frightening like walking down a dark alleyway, hearing unfamiliar sounds, or seeing unfamiliar people