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In addition to its important role in apoptosis, ER is likewise at the crossroads of two pathways, apoptosis and autophagy, in the diabetes process (134), Melatonin (MEL) as an antioxidant and anti-inflammatory agent was found to play a role in the ER major stress response (135)

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By integrating lipidomics with transcriptomic analyses, the authors showed that defective lipid class switching may contribute to persistent tumor-associated inflammation and colorectal cancer progression (Soundararajan et al., 2025)