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Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)
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Again, the antitumor effect of Epitalon was confirmed in a 6.5-month-long study by comparing the tumor incidence, localization, and type compared to a control group treated with saline subcutaneously [71]
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