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Vaccinia-related kinase 2 inhibition elicits vulnerability of glutathione metabolism in pancreatic cancer | Cell Death & Disease

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Glossary ATP Adenosine triphosphate AMPK activated Protein Kinase ARDS Acute respiratory distress syndrome AKI Acute kidney injury CARS Compensatory Anti-inflammatory Response Syndrome cGAS Cyclic GMP-AMP synthase cGAMP Cyclic GMP-AMP CPB Cardiopulmonary bypass CRS Cytokine Release Syndrome CKD Chronic Kidney Disease DAMPs Damage-associated molecular patterns MARS Mixed Antagonist Response Syndrome mtDAMPs Mitochondrial damage-associated molecular patterns mtDNA Mitochondrial DNA MyD88 Myeloid differentiation primary response 88 MAS Macrophage Activation Syndrome mPTP mitochondrial permeability transition pore MDSCs Myeloid-derived suppressor cells mTORC mammalian Target of Rapamycin Complex NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells NAD+ Nicotinamide Adenine Dinucleotide NLRP3 NLR family pyrin domain containing 3 NR4A Nuclear receptor subfamily 4 group A ROS Reactive oxygen species RNS Reactive Nitrogen Species STING Stimulator of interferon genes TLR9 Toll-like receptor 9 TOX Thymocyte selection-associated high mobility group box protein IRF3 Interferon regulatory factor 3 TBK1 TANK-binding kinase 1 IL-1β Interleukin-1 beta IL-6 Interleukin-6 IL-1 Interleukin-1 TNF-α Tumor necrosis factor-alpha IFN Interferon SIRS Systemic inflammatory response syndrome IR Ischemiareperfusion ICU Intensive care unit the cGAS-STING pathway Cyclic GMP-AMP synthase–stimulator of interferon genes pathway PD-1 Programmed cell death protein 1 PD-L1 Programmed cell death ligand 1 POCD Postoperative cognitive dysfunction References 1 BartelsKKarhausenJClambeyETGrenzAEltzschigHK