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Finding Objective Assessment The challenge with spine surgery is that most surgeons recommend what they know how to do, rather than what is best for the patient
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We classified as high-impact variants those predicted as start-lost, stop-gained, stop-lost, splice-donor, splice-acceptor or frameshift, collectively called loss-of-function variants, whereas moderate impact variants are those predicted to otherwise affect coding or splicing of a protein (missense)
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