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Heffernan and colleagues (Am J Physiol Endocrinol Metab, 2000) reported that oral administration of the fragment altered lipid metabolism in rats, and the group's follow-up in obese mice and β3-adrenergic receptor knock-out mice (Endocrinology, 2001) is the most-cited study in the field: chronic treatment reduced body weight and body fat, restored the depressed β3-adrenergic receptor expression of obese mice toward lean levels, and did so without raising IGF-1 or impairing glucose handling

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